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CS-W001157 4
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(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid

  • CAS No. 193693-67-3

  • Cat. No. CS-W011865
  • Purity≥98%
  • MDL No.MFCD04112683

*For research and further manufacturing use only, not for direct human use.

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid|CS-W011865

Structure of 193693-67-3

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General Information

  • CAS No. 193693-67-3
  • Cat. No. CS-W011865
  • Purity ≥98%
  • MDL No. MFCD04112683
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₁NO₄
  • Molecular Weight 351.40
  • Synonym(s) N-(9-FLUORENYLMETHOXYCARBONYL)-N-(R)-PIPERIDINE-3-CARBOXYLIC ACID
  • SMILES O=C([C@H]1CN(C(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)CCC1)O

Description

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid is a chiral, bench-stable building block featuring a fluorenylmethoxycarbonyl (Fmoc) protected piperidine-3-carboxylic acid scaffold. This configuration enables direct incorporation into peptide synthesis workflows, where the Fmoc group ensures orthogonal protection and efficient deprotection under mild basic conditions.

Application

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid serves as a robust chiral building block for peptide and heterocyclic synthesis, offering high stereochemical integrity and bench-stable protection of both amine and carboxylic acid functionalities. Its fluorenylmethoxycarbonyl (Fmoc) group enables orthogonal deprotection in standard solid-phase workflows, while the piperidine-3-carboxylic acid core facilitates incorporation into bioactive scaffolds. The compound exhibits excellent functional group tolerance and simplifies purification through crystallization or chromatographic separation.

Synthesis

  • Route1

    References

    • Helvetica Chimica Acta, , vol. 88, # 8 p. 2235 - 2249
  • Route2

    References

    • Helvetica Chimica Acta, , vol. 88, # 8 p. 2235 - 2249
  • Route3
    • null|null
      637337-43-0
    • ~%
    • In-stock
      (R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid|CS-W011865
      193693-67-3

    References

    • Helvetica Chimica Acta, , vol. 88, # 8 p. 2235 - 2249

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   3.7321
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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