8-Bromo-3-fluoroquinolin-2(1H)-one

Name: 8-Bromo-3-fluoroquinolin-2(1H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 834883-96-4
Cat. No. CS-0068200
Molecule weight242.04
Purity≥97%
MDL No.MFCD30177936

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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8-Bromo-3-fluoroquinolin-2(1H)-one|CS-0068200

Structure of 834883-96-4

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General Information

CAS No. 834883-96-4
Cat. No. CS-0068200
Purity ≥97%
MDL No. MFCD30177936
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅BrFNO
Molecular Weight 242.04
Synonym(s) 8-Bromo-3-fluoro-2-hydroxyquinoline
SMILES BrC1=C2C(C=C(C(N2)=O)F)=CC=C1

Description

8-Bromo-3-fluoroquinolin-2(1H)-one features a sterically hindered, electron-deficient quinolinone core with dual halogen substituents. This scaffold enables direct functionalization in cross-coupling reactions and serves as a key building block for bioactive heterocycles. The molecule exhibits enhanced stability under standard bench conditions and facilitates efficient derivatization in medicinal chemistry workflows.

Application

8-Bromo-3-fluoroquinolin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C-2 position via nucleophilic substitution or transition-metal-catalyzed coupling. The bromo and fluoro substituents offer orthogonal reactivity for late-stage diversification, while the quinolinone core provides inherent stability and favorable pharmacophoric properties. Its bench-stable crystalline form facilitates handling and purification in multi-step syntheses.

Synthesis

Route1
- 615-36-1
- ~%
- In-stock
  
  834883-96-4
References
- Ondi, Levente; Volle, Jean-Noel; Schlosser, Manfred Tetrahedron, 2005 , vol. 61, # 3 p. 717 - 725

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 32.86
LogP 2.4297
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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8-Bromo-3-fluoroquinolin-2(1H)-one

CAS No. 834883-96-4

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