5-Bromo-8-fluoroquinoline

Name: 5-Bromo-8-fluoroquinoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1133115-78-2
Cat. No. CS-0063938
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1133115-78-2

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General Information

CAS No. 1133115-78-2
Cat. No. CS-0063938
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅BrFN
Molecular Weight 226.05
Synonym(s) 5-bromo-8-fluoro-quinoline
SMILES FC1=C2N=CC=CC2=C(Br)C=C1

Description

5-Bromo-8-fluoroquinoline delivers a strategically positioned halogen pair that enhances reactivity in cross-coupling processes. The electron-deficient quinoline core supports transition metal catalysis, while the orthogonal halogens enable selective functionalization. This scaffold integrates readily into pharmaceutical and materials chemistry platforms.

Application

5-Bromo-8-fluoroquinoline serves as a versatile building block in medicinal chemistry and materials science, enabling direct functionalization at both the 5-bromo and 8-fluoro positions via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its dual electrophilic sites offer orthogonal reactivity for modular scaffold construction, while its bench-stable crystalline form facilitates handling and purification in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  2924-09-6
- 107-02-8
- ~%
- In-stock
  
  1133115-78-2
References
- WO2010/94643 A1, ; Page/Page column 55 ; WO 2010/094643 A1
Route2
- In-stock
  
  2924-09-6
- In-stock
  
  56-81-5
- ~%
- In-stock
  
  1133115-78-2
References
- WO2010/30722 A1, ; Page/Page column 41-42 ; WO 2010/030722 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 12.89
LogP 3.1364
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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5-Bromo-8-fluoroquinoline

CAS No. 1133115-78-2

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