2-Bromo-3-fluoropyrazine

Name: 2-Bromo-3-fluoropyrazine
Brand: ChemScene
Availability: InStock
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CAS No. 206278-27-5
Cat. No. CS-0059874
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 206278-27-5

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Description

2-Bromo-3-fluoropyrazine is a halogenated pyrazine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromine at the 2-position enables palladium-catalyzed coupling, while the fluorine at the 3-position offers orthogonal reactivity or enhanced electronic modulation. This dual-heteroatom pattern supports precise molecular diversification in medicinal chemistry and materials synthesis.

Application

2-Bromo-3-fluoropyrazine serves as a versatile building block in the synthesis of functionalized pyrazine scaffolds, enabling palladium-catalyzed cross-coupling reactions and nucleophilic substitution processes. Its complementary halogenation pattern facilitates sequential functionalization, while its bench-stable nature supports reliable handling in multi-step synthetic sequences for medicinal chemistry and agrochemical applications.

General Information

CAS No. 206278-27-5
Cat. No. CS-0059874
Purity ≥98%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂BrFN₂
Molecular Weight 176.97
Synonym(s) None
SMILES C=1(C(=NC=CN1)F)Br

Computational Chemistry Data

TPSA 25.78
LogP 1.3782
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Bromo-3-fluoropyrazine

CAS No. 206278-27-5

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