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CS-W001157 4
Total: USD 88.00

2-Bromo-6-fluoropyrazine

  • CAS No. 1209458-12-7

  • Cat. No. CS-0161312
  • Purity≥97%
  • MDL No.MFCD14702734

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-fluoropyrazine|CS-0161312

Structure of 1209458-12-7

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General Information

  • CAS No. 1209458-12-7
  • Cat. No. CS-0161312
  • Purity ≥97%
  • MDL No. MFCD14702734
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrFN₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES FC1=CN=CC(Br)=N1

Description

2-Bromo-6-fluoropyrazine is a halogenated pyrazine derivative featuring complementary reactive sites for cross-coupling. The bromo group enables palladium-catalyzed transformations, while the fluorine atom facilitates nucleophilic substitution or further functionalization. This bifunctional architecture supports modular synthesis in medicinal chemistry and materials science.

Application

2-Bromo-6-fluoropyrazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromine and fluorine substituents offer orthogonal functionalization potential, facilitating sequential derivatization. Its stability under standard synthetic conditions and compatibility with diverse reaction partners make it well-suited for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H226-H302-H315-H318-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.3782
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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