2-Bromo-5-fluoropyrazine

Name: 2-Bromo-5-fluoropyrazine
Brand: ChemScene
Availability: InStock
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CAS No. 1209459-10-8
Cat. No. CS-0043702
Purity≥95%
MDL No.MFCD14702726

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1209459-10-8

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Description

2-Bromo-5-fluoropyrazine is a halogenated pyrazine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromo group enables palladium-catalyzed transformations, while the fluorine atom supports nucleophilic substitution under mild conditions. This bifunctional scaffold facilitates rapid diversification in medicinal chemistry and materials synthesis.

Application

2-Bromo-5-fluoropyrazine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromine and fluorine substituents facilitate sequential functionalization, while the pyrazine core provides structural rigidity and enhanced bioavailability in target molecules. This compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for scalable synthesis workflows.

General Information

CAS No. 1209459-10-8
Cat. No. CS-0043702
Purity ≥95%
MDL No. MFCD14702726
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂BrFN₂
Molecular Weight 176.97
Synonym(s) 5-bromo-2-fluoropyrazine
SMILES FC1=CN=C(Br)C=N1

Computational Chemistry Data

TPSA 25.78
LogP 1.3782
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Bromo-5-fluoropyrazine

CAS No. 1209459-10-8

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