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CS-W001157 4
Total: USD 88.00

2-Fluoropyrazine

  • CAS No. 4949-13-7

  • Cat. No. CS-W013727
  • Purity≥95%
  • MDL No.MFCD03094084

*For research and further manufacturing use only, not for direct human use.

2-Fluoropyrazine|CS-W013727

Structure of 4949-13-7

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General Information

  • CAS No. 4949-13-7
  • Cat. No. CS-W013727
  • Purity ≥95%
  • MDL No. MFCD03094084
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃FN₂
  • Molecular Weight 98.08
  • Synonym(s) Fluoropyrazine
  • SMILES FC1=CN=CC=N1

Description

2-Fluoropyrazine is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the 2-position, enabling selective functionalization in cross-coupling reactions. This nitrogen-rich scaffold integrates readily into pharmaceutical intermediates and agrochemicals, offering enhanced reactivity and metabolic stability.

Application

2-Fluoropyrazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyrazine ring via nucleophilic substitution due to the activating effect of the fluorine atom. Its bench-stable nature and compatibility with standard cross-coupling reactions facilitate efficient synthesis of heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225-H302-H315-H318-H335
Precautionary Statements : P210-P261-P280

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   0.6157
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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