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CS-W001157 4
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(2-(Trifluoromethyl)pyridin-3-yl)methanol

  • CAS No. 131747-57-4

  • Cat. No. CS-0103066
  • Purity≥95%
  • MDL No.MFCD11100743

*For research and further manufacturing use only, not for direct human use.

(2-(Trifluoromethyl)pyridin-3-yl)methanol|CS-0103066

Structure of 131747-57-4

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General Information

  • CAS No. 131747-57-4
  • Cat. No. CS-0103066
  • Purity ≥95%
  • MDL No. MFCD11100743
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃NO
  • Molecular Weight 177.12
  • Synonym(s) (2-Trifluoromethyl-pyridin-3-yl)-methanol
  • SMILES OCC1=CC=CN=C1C(F)(F)F

Description

This trifluoromethyl-substituted pyridylmethanol features a reactive alcohol group positioned ortho to the electron-withdrawing trifluoromethyl moiety, enhancing its utility in cross-coupling and functionalization reactions. The molecule exhibits enhanced stability and solubility in polar organic solvents, enabling straightforward incorporation into complex molecular architectures under standard conditions.

Application

(2-(Trifluoromethyl)pyridin-3-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of a trifluoromethylated pyridine motif into target molecules. Its benzyl alcohol functionality facilitates straightforward derivatization via oxidation, protection, or coupling reactions. The molecule exhibits good bench stability and functional group tolerance, supporting its use in multi-step syntheses of bioactive compounds and API intermediates.

Synthesis

  • Route1

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 41, # 12 p. 2146 - 2163
  • Route3
    • 2,2,2-Trifluoro-1-(2-(trifluoromethyl)pyridin-3-yl)ethan-1-one|CS-1214803
      208517-34-4
    • ~%
    • In-stock
      (2-(Trifluoromethyl)pyridin-3-yl)methanol|CS-0103066
      131747-57-4

    References

    • Journal of Medicinal Chemistry, , vol. 41, # 12 p. 2146 - 2163

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5927
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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