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CS-W001157 4
Total: USD 88.00

2-Chloro-3-pyridinol

  • CAS No. 6636-78-8

  • Cat. No. CS-D0978
  • Purity≥98%
  • MDL No.MFCD00006235

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-pyridinol|CS-D0978

Structure of 6636-78-8

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General Information

  • CAS No. 6636-78-8
  • Cat. No. CS-D0978
  • Purity ≥98%
  • MDL No. MFCD00006235
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClNO
  • Molecular Weight 129.55
  • Synonym(s) None
  • SMILES OC1=CC=CN=C1Cl

Description

2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2( 1 H)-selone. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves and -activation of chloropyridines, as well as palladium-mediated reactions.

Application

2-Chloro-3-pyridinol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C3 position of the pyridine ring. Its chloride moiety facilitates nucleophilic substitution reactions, while the phenolic hydroxyl group provides a handle for derivatization or metal-catalyzed coupling processes. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • null|null
      163083-47-4
    • ~92%
    • In-stock
      2-Chloro-3-pyridinol|CS-D0978
      6636-78-8

    References

    • Green, Alice E.; Agouridas, Vangelis; Deniau, Eric Tetrahedron Letters, 2013 , vol. 54, # 51 p. 7078 - 7079
  • Route2

    References

    • Voisin, Anne Sophie; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain Tetrahedron, 2005 , vol. 61, # 6 p. 1417 - 1421
  • Route3

    References

    • Tetrahedron, , vol. 61, # 6 p. 1417 - 1421

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.4406
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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