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2-Chloro-4-fluoropyridin-3-ol

  • CAS No. 1227577-96-9

  • Cat. No. CS-0161369
  • Molecule weight147.53
  • Purity≥95%
  • MDL No.MFCD16610317

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-fluoropyridin-3-ol|CS-0161369

Structure of 1227577-96-9

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General Information

  • CAS No. 1227577-96-9
  • Cat. No. CS-0161369
  • Purity ≥95%
  • MDL No. MFCD16610317
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFNO
  • Molecular Weight 147.53
  • Synonym(s) 2-CHLORO-4-FLUORO-3-HYDROXYPYRIDINE
  • SMILES OC1=C(F)C=CN=C1Cl

Description

2-Chloro-4-fluoropyridin-3-ol features a trifunctional pyridine core with chlorine and fluorine substituents at the 2- and 4-positions, respectively, and a phenolic hydroxyl group at the 3-position. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates. The hydroxyl moiety enhances solubility and facilitates derivatization under mild conditions.

Application

2-Chloro-4-fluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based heterocycles. Its orthogonal halogen and hydroxyl functionalities facilitate selective coupling reactions, including palladium-catalyzed cross-couplings and nucleophilic substitutions. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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