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Structure of 1227577-96-9
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2-Chloro-4-fluoropyridin-3-ol features a trifunctional pyridine core with chlorine and fluorine substituents at the 2- and 4-positions, respectively, and a phenolic hydroxyl group at the 3-position. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates. The hydroxyl moiety enhances solubility and facilitates derivatization under mild conditions.
2-Chloro-4-fluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based heterocycles. Its orthogonal halogen and hydroxyl functionalities facilitate selective coupling reactions, including palladium-catalyzed cross-couplings and nucleophilic substitutions. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: