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CS-W001157 4
Total: USD 88.00

2,6-Dichloro-3-hydroxypyridine

  • CAS No. 52764-11-1

  • Cat. No. CS-0195788
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloro-3-hydroxypyridine|CS-0195788

Structure of 52764-11-1

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General Information

  • CAS No. 52764-11-1
  • Cat. No. CS-0195788
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂NO
  • Molecular Weight 163.99
  • Synonym(s) 2,6-Dichloropyridin-3-ol
  • SMILES C1=CC(=NC(=C1O)Cl)Cl

Description

2,6-Dichloro-3-hydroxypyridine features a pyridine core functionalized with two chlorine atoms at the 2 and 6 positions and a hydroxyl group at the 3 position. This electron-deficient heterocycle serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, offering enhanced reactivity in nucleophilic substitution processes. The ortho-chlorine arrangement provides steric protection to the hydroxyl group, improving stability under standard handling conditions.

Application

2,6-Dichloro-3-hydroxypyridine serves as a versatile building block for functionalized pyridine scaffolds, enabling direct substitution at the C3 position via nucleophilic displacement or metal-catalyzed coupling. The hydroxyl group provides a handle for derivatization, while the ortho-dichloro substitution pattern ensures high reactivity and regioselective transformation under mild conditions. Its bench-stable nature and compatibility with common protecting group strategies make it ideal for iterative synthesis in medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.094
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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