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2-Chloro-4-methylpyridin-3-ol

  • CAS No. 884494-70-6

  • Cat. No. CS-0153648
  • Purity≥98%
  • MDL No.MFCD04112564

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-methylpyridin-3-ol|CS-0153648

Structure of 884494-70-6

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General Information

  • CAS No. 884494-70-6
  • Cat. No. CS-0153648
  • Purity ≥98%
  • MDL No. MFCD04112564
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO
  • Molecular Weight 143.57
  • Synonym(s) 2-chloro-4-methyl-pyridin-3-ol
  • SMILES CC1=C(C(=NC=C1)Cl)O

Description

2-Chloro-4-methylpyridin-3-ol features a pyridin-3-ol core with strategically positioned chloro and methyl groups, enabling selective nucleophilic substitution. The electron-deficient ring facilitates coupling reactions, while the phenolic OH offers hydrogen-bonding capacity. This scaffold integrates readily into bioactive molecules and serves as a key intermediate in agrochemical and pharmaceutical synthesis under standard conditions.

Application

2-Chloro-4-methylpyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via nucleophilic substitution. Its chloro group exhibits high reactivity toward amines, thiols, and other nucleophiles under mild conditions, facilitating rapid diversification. The pyridinol functionality provides hydrogen-bonding capability and enhances solubility, while the methyl group offers modest steric influence. Bench-stable and readily purified by recrystallization or chromatography, it functions reliably in standard coupling workflows for API intermediate synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.74902
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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