Mc-Val-Cit-OH

Name: Mc-Val-Cit-OH
Brand: ChemScene
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CAS No. 916746-27-5
Cat. No. CS-0198427
Molecule weight467.52
Purity≥97%
MDL No.MFCD32670275

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 916746-27-5

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General Information

CAS No. 916746-27-5
Cat. No. CS-0198427
Purity ≥97%
MDL No. MFCD32670275
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₃₃N₅O₇
Molecular Weight 467.52
Synonym(s) (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanoicacid
SMILES O=C(O)[C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O

Description

Mc-Val-Cit-OH is a stable, cleavable linker peptide designed for antibody-drug conjugate (ADC) applications. Featuring a valine-citrulline dipeptide motif, it enables site-specific payload release within target cells. The terminal hydroxyl group facilitates conjugation to antibody payloads under standard conditions.

Application

Mc-Val-Cit-OH serves as a well-established linker for antibody-drug conjugates, enabling site-specific payload attachment via amide bond formation. Its valine-citrulline dipeptide motif provides protease-sensitive cleavage under physiological conditions, facilitating controlled drug release. The terminal carboxylic acid offers direct conjugation capability to antibodies or solid supports, while the structure exhibits robust bench stability and compatibility with standard purification protocols.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 188
LogP -0.3695
H_Acceptors 6
H_Donors 5
Rotatable_Bonds 15

Other Classifications

Life Science Linker Peptide Linkers

Chemical Biology PEGylation PEG Oligomers

Key Words

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Mc-Val-Cit-OH

CAS No. 916746-27-5

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