Mc-Val-Cit-OH

Name: Mc-Val-Cit-OH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 916746-27-5
Cat. No. CS-0198427
Purity≥97%
MDL No.MFCD32670275

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 916746-27-5

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Description

Mc-Val-Cit-OH is a stable, cleavable linker peptide designed for antibody-drug conjugate (ADC) applications. Featuring a valine-citrulline dipeptide motif, it enables site-specific payload release within target cells. The terminal hydroxyl group facilitates conjugation to antibody payloads under standard conditions.

Application

Mc-Val-Cit-OH serves as a well-established linker for antibody-drug conjugates, enabling site-specific payload attachment via amide bond formation. Its valine-citrulline dipeptide motif provides protease-sensitive cleavage under physiological conditions, facilitating controlled drug release. The terminal carboxylic acid offers direct conjugation capability to antibodies or solid supports, while the structure exhibits robust bench stability and compatibility with standard purification protocols.

General Information

CAS No. 916746-27-5
Cat. No. CS-0198427
Purity ≥97%
MDL No. MFCD32670275
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₃₃N₅O₇
Molecular Weight 467.52
Synonym(s) (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanoicacid
SMILES O=C(O)[C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O

Computational Chemistry Data

TPSA 188
LogP -0.3695
H_Acceptors 6
H_Donors 5
Rotatable_Bonds 15

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Other Classifications

Life Science Linker Peptide Linkers

Chemical Biology PEGylation PEG Oligomers

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Mc-Val-Cit-OH

CAS No. 916746-27-5

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