MC-Val-Ala-OH

Name: MC-Val-Ala-OH
Brand: ChemScene
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CAS No. 1342211-31-7
Cat. No. CS-0020920
Molecule weight381.42
Purity≥98%
MDL No.MFCD27956998

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1342211-31-7
Cat. No. CS-0020920
Purity ≥98%
MDL No. MFCD27956998
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₇N₃O₆
Molecular Weight 381.42
Synonym(s) None
SMILES C[C@@H](C(O)=O)NC([C@H](C(C)C)NC(CCCCCN1C(C=CC1=O)=O)=O)=O

Description

MC-Val-Ala-OH is a dipeptide derivative featuring a C-terminal carboxylic acid, offering enhanced stability and solubility in aqueous systems. This sequence integrates a valine-alanine motif with a methylcyclopropyl group at the N-terminus, enabling efficient coupling in peptide synthesis workflows. The molecule's defined stereochemistry supports high-fidelity incorporation into larger peptide architectures under standard conditions.

Application

MC-Val-Ala-OH serves as a well-established dipeptide building block for solid-phase peptide synthesis, offering robust bench stability and compatibility with standard coupling protocols. Its N-terminal methylcarbamate (MC) protection enables selective deprotection under mild conditions, facilitating efficient chain elongation. The Val-Ala sequence provides orthogonal handling in multi-step syntheses and demonstrates favorable solubility and purification characteristics, making it a reliable intermediate for peptide-based API development and fragment assembly.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 132.88
LogP 0.2019
H_Acceptors 5
H_Donors 3
Rotatable_Bonds 11

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrroline compounds

Life Science Linker Maleimide Linkers

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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MC-Val-Ala-OH

CAS No. 1342211-31-7

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