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CS-W001157 4
Total: USD 88.00

4-Bromo-2,5-difluoropyridine

  • CAS No. 1349718-16-6

  • Cat. No. CS-0060143
  • Purity≥97%
  • MDL No.MFCD19686165

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2,5-difluoropyridine|CS-0060143

Structure of 1349718-16-6

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General Information

  • CAS No. 1349718-16-6
  • Cat. No. CS-0060143
  • Purity ≥97%
  • MDL No. MFCD19686165
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrF₂N
  • Molecular Weight 193.98
  • Synonym(s) None
  • SMILES FC1=CN=C(F)C=C1Br

Description

4-Bromo-2,5-difluoropyridine is a fluorinated heterocyclic building block featuring complementary halogen handles for cross-coupling reactions. The electron-deficient pyridine core enhances reactivity in palladium-catalyzed processes, while the bromo and difluoro substituents offer orthogonal functionalization potential. This bench-stable compound enables efficient access to diverse pharmaceutical intermediates and advanced materials.

Application

4-Bromo-2,5-difluoropyridine serves as a versatile building block in medicinal chemistry and cross-coupling synthesis. The bromo group enables palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings, while the difluoro substitution pattern enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient assembly of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.1223
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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