3-Cyanobicyclo[1.1.1]pentane-1-carboxylic acid

Name: 3-Cyanobicyclo[1.1.1]pentane-1-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 83249-02-9
Cat. No. CS-0056908
Purity≥95%
MDL No.MFCD19229172

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Cyanobicyclo[1.1.1]pentane-1-carboxylic acid|CS-0056908

Structure of 83249-02-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 83249-02-9
Cat. No. CS-0056908
Purity ≥95%
MDL No. MFCD19229172
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇NO₂
Molecular Weight 137.14
Synonym(s) None
SMILES O=C(C1(C2)CC2(C#N)C1)O

Description

3-Cyanobicyclo[1.1.1]pentane-1-carboxylic acid delivers a rigid, electron-deficient scaffold ideal for probing steric and electronic effects in medicinal chemistry. The strained bicyclic core enhances metabolic stability, while the nitrile and carboxylic acid groups enable diverse conjugation strategies. This compound serves as a potent bioisostere in lead optimization campaigns.

Application

3-Cyanobicyclo[1.1.1]pentane-1-carboxylic acid is a rigid, three-dimensional building block that serves as a versatile scaffold in medicinal chemistry and synthetic organic chemistry. Its strained bicyclic core imparts high metabolic stability and conformational restriction, enabling precise spatial orientation of functional groups. The pendant nitrile and carboxylic acid moieties offer orthogonal reactivity—facilitating amide coupling, nucleophilic addition, or derivatization—while the molecule exhibits excellent bench stability and ease of purification. This compound functions as a key intermediate in the synthesis of bioactive molecules requiring constrained geometries and enhanced physicochemical properties.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 61.09
LogP 0.76488
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

83249-02-9 sigma83249-02-9 manufacturer83249-02-9 price83249-02-9 structure83249-02-9 SDSbuy 83249-02-983249-02-9 supplier83249-02-9 uses83249-02-9 molecular weightprice of 83249-02-983249-02-9 chemical name formula of 83249-02-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3-Cyanobicyclo[1.1.1]pentane-1-carboxylic acid

CAS No. 83249-02-9

Recommended Products