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CS-W001157 4
Total: USD 88.00

5,7-Dichlorothieno[3,2-b]pyridine

  • CAS No. 74695-44-6

  • Cat. No. CS-0019303
  • Purity≥98%
  • MDL No.MFCD09953620

*For research and further manufacturing use only, not for direct human use.

5,7-Dichlorothieno[3,2-b]pyridine|CS-0019303

Structure of 74695-44-6

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General Information

  • CAS No. 74695-44-6
  • Cat. No. CS-0019303
  • Purity ≥98%
  • MDL No. MFCD09953620
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃Cl₂NS
  • Molecular Weight 204.08
  • Synonym(s) 5,7-dichlorothienopyridine
  • SMILES ClC1=C2C(C=CS2)=NC(Cl)=C1

Description

5,7-Dichlorothieno[3,2-b]pyridine is a heterocyclic scaffold featuring two chlorine substituents at the 5 and 7 positions, enhancing electron deficiency and enabling robust coupling reactions. This bench-stable core integrates readily into advanced synthetic architectures for pharmaceuticals and functional materials.

Application

5,7-Dichlorothieno[3,2-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its dual chlorine substituents enable selective cross-coupling reactions, facilitating the construction of complex scaffolds under palladium-catalyzed conditions. The molecule exhibits excellent bench stability and compatibility with standard functional groups, making it well-suited for iterative synthesis workflows and scale-up applications.

Synthesis

  • Route1
    • Thiophen-3-amine|CS-0096335
      17721-06-1
    • null|null
      141-82-2
    • ~%
    • In-stock
      5,7-Dichlorothieno[3,2-b]pyridine|CS-0019303
      74695-44-6

    References

    • WO2008/118718 A2, ; Page/Page column 60 ;
  • Route2
    • 7-Hydroxythieno[3,2-b]pyridin-5(4H)-one|CS-0159642
      74695-40-2
    • ~49%
    • 7-Chlorothieno[3,2-b]pyridin-5(4H)-one|CS-0530327
      74695-45-7
    • In-stock
      5,7-Dichlorothieno[3,2-b]pyridine|CS-0019303
      74695-44-6

    References

    • Journal of Chemical Research, Miniprint, , # 1 p. 113 - 126
  • Route3

    References

    • Journal of Chemical Research, Miniprint, , # 1 p. 113 - 126

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.6031
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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