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CS-W001157 4
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5,7-dichloro-3-ethylpyrazolo[1,5-a]pyrimidine

  • CAS No. 779353-64-9

  • Cat. No. CS-B0797
  • Purity≥95%
  • MDL No.MFCD08448153

*For research and further manufacturing use only, not for direct human use.

5,7-dichloro-3-ethylpyrazolo[1,5-a]pyrimidine|CS-B0797

Structure of 779353-64-9

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General Information

  • CAS No. 779353-64-9
  • Cat. No. CS-B0797
  • Purity ≥95%
  • MDL No. MFCD08448153
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇Cl₂N₃
  • Molecular Weight 216.07
  • Synonym(s) Pyrazolo[1,5-a]pyrimidine, 5,7-dichloro-3-ethyl- (9CI)
  • SMILES CCC1=C2N=C(Cl)C=C(Cl)N2N=C1

Description

5,7-Dichloro-3-ethylpyrazolo[1,5-a]pyrimidine features a rigid heteroaromatic core with strategically positioned electron-withdrawing chloro groups and a lipophilic ethyl substituent. This combination enhances its utility in constructing bioactive scaffolds, particularly in kinase inhibitor development and medicinal chemistry campaigns requiring moderate metabolic stability and controlled reactivity under standard conditions.

Application

5,7-Dichloro-3-ethylpyrazolo[1,5-a]pyrimidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its electron-deficient pyrazolopyrimidine core facilitates nucleophilic substitution and palladium-catalyzed coupling reactions. The dichloro substituents provide orthogonal reactivity for selective functionalization, while the ethyl group enhances solubility and modulates electronic properties. Bench-stable and amenable to standard purification methods, it functions reliably in multi-step syntheses targeting bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.5985
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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