5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine

Name: 5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 771510-32-8
Cat. No. CS-W000401
Purity≥97%
MDL No.MFCD12923044

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine|CS-W000401

Structure of 771510-32-8

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General Information

CAS No. 771510-32-8
Cat. No. CS-W000401
Purity ≥97%
MDL No. MFCD12923044
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₉Cl₂N₃
Molecular Weight 230.09
Synonym(s) 3-isopropyl-5,7-dichloropyrazolo[1,5-a]pyrimidine
SMILES Clc1cc(Cl)n2c(n1)c(cn2)C(C)C

Description

5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine features a sterically hindered isopropyl group flanking an electron-deficient pyrazolopyrimidine core, enhancing metabolic stability and enabling selective integration into kinase inhibitor scaffolds. This scaffold delivers robust reactivity under standard conditions for medicinal chemistry applications.

Application

5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of purine-like scaffolds. Its dichloro substitution pattern facilitates selective functionalization at C5 and C7, while the isopropyl group enhances solubility and modulates electronic properties. The scaffold exhibits excellent bench stability and compatibility with standard coupling reactions, supporting rapid diversification in kinase inhibitor and nucleoside analog development.

Synthesis

Route1
- 771510-25-9
- ~85%
- In-stock
  
  771510-32-8
References
- VERNALIS (CAMBRIDGE) LIMITED Patent: WO2004/87707 A1, 2004 ; Location in patent: Page 27; 29 ; WO 2004/087707 A1
Route2
- 771510-25-9
- 121-69-7
- ~79%
- In-stock
  
  771510-32-8
References
- EMORY UNIVERSITY; IMPERIAL COLLEGE OF SCIENCE AND TECHNOLOGY; JOGALEKAR, Ashutosh, S. Patent: WO2008/151304 A1, 2008 ; Location in patent: Page/Page column 113-115 ;
Route3
- 625-28-5
- ~%
- In-stock
  
  771510-32-8
References
- Liotta, Dennis C.; Snyder, James P.; Jogalekar, Ashutosh S.; Barrett, Anthony G.M.; Fuchter, Matthew John; Cook, Matthew J.; Kroll, Sebastian H.B. Patent: US2012/41198 A1, 2012 ; US 20120041198 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 30.19
LogP 3.1595
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

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5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine

CAS No. 771510-32-8

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