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CS-W001157 4
Total: USD 88.00

2-Bromo-4-methoxybenzoic acid

  • CAS No. 74317-85-4

  • Cat. No. CS-W005678
  • Purity≥97%
  • MDL No.MFCD11044843

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-methoxybenzoic acid|CS-W005678

Structure of 74317-85-4

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General Information

  • CAS No. 74317-85-4
  • Cat. No. CS-W005678
  • Purity ≥97%
  • MDL No. MFCD11044843
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrO₃
  • Molecular Weight 231.04
  • Synonym(s) Benzoicacid,2-bromo-4-methoxy
  • SMILES O=C(O)C1=CC=C(OC)C=C1Br

Description

2-Bromo-4-methoxybenzoic acid features a bromine substituent at the ortho position relative to the carboxylic acid, paired with a methoxy group at the para position, delivering enhanced electron-withdrawing character and improved solubility in organic solvents. This combination enables efficient coupling reactions and facilitates downstream derivatization in synthetic pathways.

Synthesis

  • Route1

    References

    • Wei, Hao; Zhang, Yong Jian; Wang, Feijun; Zhang, Wanbin Tetrahedron Asymmetry, 2008 , vol. 19, # 4 p. 482 - 488
  • Route2
    • null|null
      59142-57-3
    • ~95%
    • In-stock
      2-Bromo-4-methoxybenzoic acid|CS-W005678
      74317-85-4

    References

    • SHANGHAI JIAOTONG UNIVERSITY Patent: US2009/156829 A1, 2009 ; Location in patent: Page/Page column 4 ;
  • Route3
    • Ethyl 2-bromo-4-methoxybenzoate|CS-0689844
      1208075-63-1
    • ~78%
    • In-stock
      2-Bromo-4-methoxybenzoic acid|CS-W005678
      74317-85-4

    References

    • Moreno-Sanz, Guillermo; Duranti, Andrea; Melzig, Laurin; Fiorelli, Claudio; Ruda, Gian Filippo; Colombano, Giampiero; Mestichelli, Paola; Sanchini, Silvano; Tontini, Andrea; Mor, Marco; Bandiera, Tiziano; Scarpelli, Rita; Tarzia, Giorgio; Piomelli, Daniele Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5917 - 5930

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.1559
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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