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Structure of 328-89-2
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2-Bromo-4-(trifluoromethyl)benzoic acid features a strategically positioned trifluoromethyl group enhancing electron-withdrawal and metabolic stability, while the bromine substituent enables facile palladium-catalyzed cross-coupling. This combination facilitates rapid diversification in medicinal chemistry campaigns, particularly for developing bioactive heterocycles and pharmaceutical intermediates under standard conditions.
2-Bromo-4-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its well-established halogen reactivity. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid functionality allows for direct derivatization or salt formation. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows for heterocyclic and API scaffold construction.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: