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(1R)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride

  • CAS No. 731859-02-2

  • Cat. No. CS-0021528
  • Purity≥98%
  • MDL No.MFCD16295032

*For research and further manufacturing use only, not for direct human use.

(1R)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride|CS-0021528

Structure of 731859-02-2

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General Information

  • CAS No. 731859-02-2
  • Cat. No. CS-0021528
  • Purity ≥98%
  • MDL No. MFCD16295032
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁ClFN
  • Molecular Weight 187.64
  • Synonym(s) (R)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride
  • SMILES N[C@@H]1CCC2=C1C=C(F)C=C2.Cl

Description

(1R)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride offers a chiral, electron-deficient indenyl scaffold ideal for asymmetric synthesis. This bench-stable salt features a rigid, fused bicyclic core with a fluorine substituent at the 6-position, enhancing metabolic stability and modulating electronic properties. The primary amine functionality enables straightforward derivatization, facilitating incorporation into bioactive scaffolds and catalyst systems.

Application

(1R)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride serves as a chiral building block for the synthesis of bioactive indoline derivatives. Its fluorinated aromatic core provides enhanced metabolic stability and modulated electronic properties, while the secondary amine functionality enables straightforward derivatization via reductive amination, acylation, or coupling reactions. The hydrochloride salt enhances solubility and handling stability, facilitating use in standard medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.1935
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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