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CS-W001157 4
Total: USD 88.00

(1-Methyl-1H-pyrazol-5-yl)-boronic acid

  • CAS No. 720702-41-0

  • Cat. No. CS-D0545
  • Purity≥95%
  • MDL No.MFCD11053031

*For research and further manufacturing use only, not for direct human use.

(1-Methyl-1H-pyrazol-5-yl)-boronic acid|CS-D0545

Structure of 720702-41-0

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General Information

  • CAS No. 720702-41-0
  • Cat. No. CS-D0545
  • Purity ≥95%
  • MDL No. MFCD11053031
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇BN₂O₂
  • Molecular Weight 125.92
  • Synonym(s) Boronic acid, (1-methyl-1H-pyrazol-5-yl)-
  • SMILES OB(O)C1=CC=NN1C

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering functionalized heteroaryl scaffolds with high efficiency. The methyl-pyrazole framework enhances solubility and stability, enabling straightforward handling in synthetic workflows.

Application

(1-Methyl-1H-pyrazol-5-yl)-boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its stability, ease of handling, and compatibility with diverse functional groups make it well-suited for the synthesis of biaryl systems and heterocyclic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      930-36-9
    • ~98%
    • In-stock
      (1-Methyl-1H-pyrazol-5-yl)-boronic acid|CS-D0545
      720702-41-0

    References

    • ARENA PHARMACEUTICALS, INC. Patent: WO2005/12254 A1, 2005 ; Location in patent: Page/Page column 101 ; WO 2005/012254 A1
  • Route2
    • null|null
      930-36-9
    • null|null
      5419-55-6
    • ~92%
    • In-stock
      (1-Methyl-1H-pyrazol-5-yl)-boronic acid|CS-D0545
      720702-41-0

    References

    • PFIZER INC.; HELAL, Christopher J.; CHAPPIE, Thomas Allen; HUMPHREY, John M. Patent: WO2012/168817 A1, 2012 ; Location in patent: Page/Page column 44-45 ; WO 2012/168817 A1
  • Route3
    • null|null
      930-36-9
    • null|null
      121-43-7
    • ~92%
    • In-stock
      (1-Methyl-1H-pyrazol-5-yl)-boronic acid|CS-D0545
      720702-41-0

    References

    • Jorgensen, Morten; Jorgensen, Pernille N.; Christoffersen, Claus T.; Jensen, Klaus G.; Balle, Thomas; Bang-Andersen, Benny Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 196 - 204

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.28
  • LogP   -1.9001
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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