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CS-W001157 4
Total: USD 88.00

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester

  • CAS No. 847818-74-0

  • Cat. No. CS-M2919
  • Purity≥97%
  • MDL No.MFCD05861380

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester|CS-M2919

Structure of 847818-74-0

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General Information

  • CAS No. 847818-74-0
  • Cat. No. CS-M2919
  • Purity ≥97%
  • MDL No. MFCD05861380
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇BN₂O₂
  • Molecular Weight 208.07
  • Synonym(s) 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 2-(1-Methyl-1H-pyrazol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(1-methylpyrazol-5-yl)-1,3,2-dioxaborolane
  • SMILES CC1(C)C(C)(C)OB(C2=CC=NN2C)O1

Application

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its pyrazole core provides orthogonal functional group compatibility and enhanced solubility, enabling efficient late-stage diversification in medicinal chemistry. The pinacol ester moiety ensures excellent stability, simplifies purification, and facilitates reliable coupling with aryl and heteroaryl halides under standard catalytic conditions.

Synthesis

  • Route1
    • null|null
      930-36-9
    • null|null
      61676-62-8
    • ~79%
    • In-stock
      1-Methyl-1H-pyrazole-5-boronic acid pinacol ester|CS-M2919
      847818-74-0

    References

    • WO2009/158374 A2, ; Page/Page column 30 ; WO 2009/158374 A2
  • Route2
    • null|null
      5419-55-6
    • ~52%
    • In-stock
      1-Methyl-1H-pyrazole-5-boronic acid pinacol ester|CS-M2919
      847818-74-0

    References

    • WO2007/120729 A2, ; Page/Page column 62-63 ; WO 2007/120729 A2
  • Route3

    References

    • Journal of Heterocyclic Chemistry, , vol. 41, # 6 p. 931 - 939

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.28
  • LogP   0.7193
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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