4-Chloro-2,5-difluorobenzonitrile

Name: 4-Chloro-2,5-difluorobenzonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 135748-35-5
Cat. No. CS-0063913
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2,5-difluorobenzonitrile|CS-0063913

Structure of 135748-35-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 135748-35-5
Cat. No. CS-0063913
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₂ClF₂N
Molecular Weight 173.55
Synonym(s) None
SMILES N#CC1=CC(F)=C(Cl)C=C1F

Description

4-Chloro-2,5-difluorobenzonitrile features a trifunctional aromatic core with complementary reactivity for cross-coupling and nucleophilic substitution. The electron-deficient ring enables efficient palladium-catalyzed coupling, while the nitrile group serves as a handle for downstream derivatization. This bench-stable building block supports rapid access to bioactive heterocycles and pharmaceutical intermediates under standard conditions.

Application

4-Chloro-2,5-difluorobenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles via nucleophilic aromatic substitution. Its orthogonal reactivity profile—combining electrophilic sites at the 4-chloro position with electron-withdrawing nitrile and fluorine groups—facilitates selective functionalization under mild conditions. The compound exhibits excellent bench stability, simplifies purification, and supports scalable transformations in multi-step synthetic sequences.

Synthesis

Route1
- 508203-26-7
- ~%
- In-stock
  
  135748-35-5
References
- Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
Route2
- 132794-08-2
- ~%
- In-stock
  
  135748-35-5
References
- Bioorganic and Medicinal Chemistry, , vol. 20, # 17 p. 5235 - 5246
Route3
- In-stock
  
  132794-07-1
- ~%
- In-stock
  
  135748-35-5
References
- Bioorganic and Medicinal Chemistry, , vol. 20, # 17 p. 5235 - 5246

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 23.79
LogP 2.48988
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Drug Discovery Cancer PRMT5

Key Words

4-Chloro-2,5-difluorobenzonitrile sigma4-Chloro-2,5-difluorobenzonitrile manufacturer4-Chloro-2,5-difluorobenzonitrile price4-Chloro-2,5-difluorobenzonitrile structure4-Chloro-2,5-difluorobenzonitrile SDSbuy 4-Chloro-2,5-difluorobenzonitrile4-Chloro-2,5-difluorobenzonitrile supplier4-Chloro-2,5-difluorobenzonitrile uses4-Chloro-2,5-difluorobenzonitrile molecular weightprice of 4-Chloro-2,5-difluorobenzonitrile4-Chloro-2,5-difluorobenzonitrile chemical name formula of 4-Chloro-2,5-difluorobenzonitrile

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-2,5-difluorobenzonitrile

CAS No. 135748-35-5

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words