(R)-Tetrahydrofuran-2-yl-methylamine

Name: (R)-Tetrahydrofuran-2-yl-methylamine
Brand: ChemScene
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CAS No. 7202-43-9
Cat. No. CS-W011317
Purity≥97%
MDL No.MFCD00192476

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(R)-Tetrahydrofuran-2-yl-methylamine|CS-W011317

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General Information

CAS No. 7202-43-9
Cat. No. CS-W011317
Purity ≥97%
MDL No. MFCD00192476
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁NO
Molecular Weight 101.15
Synonym(s) 1-[(2R)-tetrahydrofuran-2-yl]methanamine
SMILES NC[C@@]1([H])CCCO1

Description

(R)-Tetrahydrofuran-2-yl-methylamine delivers a chiral, bench-stable scaffold for asymmetric synthesis. The tetrahydrofuran ring imparts conformational rigidity, while the primary amine enables straightforward derivatization. This configuration enhances stereocontrol in catalytic transformations and supports efficient incorporation into bioactive molecules.

Application

(R)-Tetrahydrofuran-2-yl-methylamine serves as a chiral building block for medicinal chemistry and catalytic synthesis, offering high enantiomeric purity and stability under standard reaction conditions. Its functionality enables efficient incorporation into bioactive scaffolds via amine coupling, reductive amination, or cyclization protocols. The tetrahydrofuran ring provides conformational rigidity and favorable lipophilicity, enhancing metabolic stability in lead optimization.

Safety Information

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GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Warning	UN#: 2943
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 0.1241
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Key Words

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(R)-Tetrahydrofuran-2-yl-methylamine

CAS No. 7202-43-9

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