(R)-(tetrahydrofuran-2-yl)methanamine hydrochloride

Name: (R)-(tetrahydrofuran-2-yl)methanamine hydrochloride
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CAS No. 7175-80-6
Cat. No. CS-0469844
Purity≥98%
MDL No.MFCD27965192

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(R)-(tetrahydrofuran-2-yl)methanamine hydrochloride|CS-0469844

Structure of 7175-80-6

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General Information

CAS No. 7175-80-6
Cat. No. CS-0469844
Purity ≥98%
MDL No. MFCD27965192
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₂ClNO
Molecular Weight 137.61
Synonym(s) [(2R)-oxolan-2-yl]methanamine hydrochloride
SMILES Cl.NC[C@H]1CCCO1

Description

(R)-tetrahydrofuran-2-ylmethanamine hydrochloride is a chiral amine scaffold featuring a tetrahydrofuran ring fused to a methylene-amino group, offering high stereochemical purity and enhanced solubility in polar solvents. This bench-stable derivative serves as a key building block in asymmetric synthesis, enabling efficient incorporation into catalysts, ligands, and bioactive intermediates where defined stereochemistry and controlled basicity are essential.

Application

(R)-(Tetrahydrofuran-2-yl)methanamine hydrochloride serves as a chiral building block for medicinal chemistry and asymmetric synthesis, offering a stable, bench-ready amine with high functional group tolerance. The tetrahydrofuran ring provides conformational rigidity and enhanced solubility, facilitating efficient incorporation into bioactive scaffolds. Its hydrochloride salt form ensures excellent crystallinity and ease of handling in standard peptide coupling and reductive amination workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 0.5459
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Key Words

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(R)-(tetrahydrofuran-2-yl)methanamine hydrochloride

CAS No. 7175-80-6

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