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CS-W001157 4
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Methyl 3-amino-6-bromopyrazine-2-carboxylate

  • CAS No. 6966-01-4

  • Cat. No. CS-W002702
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 3-amino-6-bromopyrazine-2-carboxylate|CS-W002702

Structure of 6966-01-4

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General Information

  • CAS No. 6966-01-4
  • Cat. No. CS-W002702
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrN₃O₂
  • Molecular Weight 232.04
  • Synonym(s) Methyl 6-Bromo-3-aminopyrazine-2-carboxylic ester
  • SMILES COC(=O)c1nc(Br)cnc1N

Description

Methyl 3-amino-6-bromopyrazine-2-carboxylate features a pyrazine core functionalized with amino, bromo, and ester groups, enabling diverse synthetic transformations. The electron-deficient heterocycle facilitates nucleophilic substitution, while the amino group offers direct derivatization potential. This bench-stable reagent integrates readily into pharmaceutical and agrochemical synthesis pathways.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB Patent: WO2007/61360 A2, 2007 ; Location in patent: Page/Page column 71 ; WO 2007/061360 A2
  • Route2
    • null|null
      67-56-1
    • In-stock
      3-Amino-6-bromopyrazine-2-carboxylic acid|CS-W005263
      486424-37-7
    • ~%
    • In-stock
      Methyl 3-amino-6-bromopyrazine-2-carboxylate|CS-W002702
      6966-01-4

    References

    • ACS Chemical Biology, , vol. 8, # 3 p. 519 - 523
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 6 p. 2266 - 2270 Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 8 p. 2784 - 2788

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.1
  • LogP   0.6079
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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