Lot numbers can be found on the outside label of a product:
3-Amino-6-bromopyrazine-2-carboxylic acid
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CAS No. 486424-37-7
- Cat. No. CS-W005263
- Purity≥95%
- MDL No.MFCD08275681
*For research and further manufacturing use only, not for direct human use.
Structure of 486424-37-7
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General Information
- CAS No. 486424-37-7
- Cat. No. CS-W005263
- Purity ≥95%
- MDL No. MFCD08275681
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₄BrN₃O₂
- Molecular Weight 218.01
- Synonym(s) 3-Amino-6-bromo-2-pyrazinecarboxylic acid
- SMILES NC1=NC=C(N=C1C(=O)O)Br
Description
3-Amino-6-bromopyrazine-2-carboxylic acid features a pyrazine core functionalized with amino, bromo, and carboxylic acid groups, enabling direct incorporation into heterocyclic scaffolds. This bench-stable derivative supports efficient coupling reactions and serves as a key intermediate in the synthesis of bioactive molecules and advanced materials.
Application
3-Amino-6-bromopyrazine-2-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct incorporation into pharmaceutical scaffolds via coupling reactions. The amino and carboxylic acid groups provide orthogonal functionalization sites, while the bromine facilitates palladium-catalyzed cross-coupling. Bench-stable and readily purified by recrystallization, it functions efficiently in standard synthetic workflows for medicinal chemistry and process development.
Synthesis
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Route1
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In-stock
16298-03-6 - ~%
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In-stock
486424-37-7
References
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ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FENG, Tao; SANGANEE, Hitesh, Jayantilal; WADA, Hiroki Patent: WO2011/89416 A1, 2011 ; WO 2011/089416 A1
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Route2
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In-stock
5424-01-1 - ~%
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In-stock
486424-37-7
References
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Forns, Pilar; Esteve, Cristina; Taboada, Lorena; Alonso, Juan Antonio; Orellana, Adelina; Maldonado, Monica; Carreno, Cristina; Ramis, Isabel; Lopez, Manel; Miralpeix, Montserrat; Vidal, Bernat Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2784 - 2788
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Route3
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In-stock
6966-01-4 - ~10%
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In-stock
486424-37-7
References
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VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; DURRANT, Steven, John; KNEGTEL, Ronald, Marcellus, Alphonsus; O'DONNELL, Michael; REAPER, Philip, Michael Patent: WO2011/143419 A1, 2011 ; Location in patent: Page/Page column 44-45 ; WO 2011/143419 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 89.1
- LogP 0.5195
- H_Acceptors 4
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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