Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

tert-Butyl (5-bromothiazol-2-yl)carbamate

  • CAS No. 405939-39-1

  • Cat. No. CS-W007907
  • Purity≥97%
  • MDL No.MFCD07368614

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (5-bromothiazol-2-yl)carbamate|CS-W007907

Structure of 405939-39-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 405939-39-1
  • Cat. No. CS-W007907
  • Purity ≥97%
  • MDL No. MFCD07368614
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BrN₂O₂S
  • Molecular Weight 279.15
  • Synonym(s) tert-butyl N-(5-bromothiazol-2-yl)carbamate
  • SMILES O=C(OC(C)(C)C)NC1=NC=C(Br)S1

Description

tert-Butyl (5-bromothiazol-2-yl)carbamate features a brominated thiazole core with a bench-stable carbamate protecting group, enabling direct incorporation into diverse synthetic sequences. This moiety delivers a reactive handle for palladium-catalyzed cross-coupling and facilitates purification through straightforward acidolysis.

Application

tert-Butyl (5-bromothiazol-2-yl)carbamate serves as a versatile building block for the synthesis of brominated thiazole-containing scaffolds. The protected amine and bromo substituent enable orthogonal functionalization in late-stage diversification, facilitating palladium-catalyzed cross-coupling reactions and subsequent deprotection under mild acidic conditions. Its bench-stable nature and compatibility with standard synthetic workflows make it ideal for medicinal chemistry and process development applications.

Synthesis

  • Route1

    References

    • Sleebs, Brad E.; Street, Ian P.; Bu, Xian; Baell, Jonathan B. Synthesis, 2010 , # 7 art. no. P16009SS, p. 1091 - 1096
  • Route2

    References

    • Lin, Shuqun; Wrobleski, Stephen T.; Hynes Jr., John; Pitt, Sidney; Zhang, Rosemary; Fan, Yi; Doweyko, Arthur M.; Kish, Kevin F.; Sack, John S.; Malley, Mary F.; Kiefer, Susan E.; Newitt, John A.; McKinnon, Murray; Trzaskos, James; Barrish, Joel C.; Dodd, John H.; Schieven, Gary L.; Leftheris, Katerina Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5864 - 5868
  • Route3

    References

    • ACHAOGEN, INC. Patent: WO2008/154642 A2, 2008 ; Location in patent: Page/Page column 274-275 ; WO 2008/154642 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   51.22
  • LogP   3.2526
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 405939-39-1 sigma405939-39-1 manufacturer405939-39-1 price405939-39-1 structure405939-39-1 SDSbuy 405939-39-1405939-39-1 supplier405939-39-1 uses405939-39-1 molecular weightprice of 405939-39-1405939-39-1 chemical name formula of 405939-39-1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label