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CS-W001157 4
Total: USD 88.00

Methyl 2-aminothiazole-5-carboxylate

  • CAS No. 6633-61-0

  • Cat. No. CS-W019982
  • Purity≥95%
  • MDL No.MFCD03788562

*For research and further manufacturing use only, not for direct human use.

Methyl 2-aminothiazole-5-carboxylate|CS-W019982

Structure of 6633-61-0

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General Information

  • CAS No. 6633-61-0
  • Cat. No. CS-W019982
  • Purity ≥95%
  • MDL No. MFCD03788562
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O₂S
  • Molecular Weight 158.18
  • Synonym(s) Methyl-2-amino-1,3-thiazol-5-carboxylat
  • SMILES O=C(OC)C1=CN=C(N)S1

Description

Methyl 2-aminothiazole-5-carboxylate features a reactive amino group and a carboxylate ester, enabling facile derivatization in synthetic routes. This bench-stable heterocycle integrates readily into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

Application

Methyl 2-aminothiazole-5-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to thiazole-based pharmacophores. Its amino and ester functionalities support diverse transformations, including amidation, Suzuki coupling, and cyclization reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting heterocyclic scaffolds.

Synthesis

  • Route1
    • null|null
      20656-61-5
    • null|null
      17356-08-0
    • ~48%
    • In-stock
      Methyl 2-aminothiazole-5-carboxylate|CS-W019982
      6633-61-0

    References

    • Noto, Renato; Ciofalo, Maurizio; Buccheri, Francesco; Werber, Guiseppe; Spinelli, Domenico Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 3 p. 349 - 352
  • Route2
    • In-stock
      Methyl 3-methoxyacrylate|CS-W007972
      34846-90-7
    • null|null
      17356-08-0
    • ~%
    • In-stock
      Methyl 2-aminothiazole-5-carboxylate|CS-W019982
      6633-61-0

    References

    • US2006/293366 A1, ; Page/Page column 13-14 ;
  • Route3
    • null|null
      107-31-3
    • null|null
      96-34-4
    • ~%
    • In-stock
      Methyl 2-aminothiazole-5-carboxylate|CS-W019982
      6633-61-0

    References

    • US6046190 A1, ; US 6046190 A US5968942 A1, ; US 5968942 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   0.5119
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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