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CS-W001157 4
Total: USD 88.00

Ethyl 2-aminothiazole-5-carboxylate

  • CAS No. 32955-21-8

  • Cat. No. CS-D0703
  • Purity≥98%
  • MDL No.MFCD00602139

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-aminothiazole-5-carboxylate|CS-D0703

Structure of 32955-21-8

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General Information

  • CAS No. 32955-21-8
  • Cat. No. CS-D0703
  • Purity ≥98%
  • MDL No. MFCD00602139
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂S
  • Molecular Weight 172.20
  • Synonym(s) None
  • SMILES O=C(OCC)C1=CN=C(N)S1

Description

Ethyl 2-aminothiazole-5-carboxylate features a reactive amino group flanked by a thiazole ring and ester functionality, enabling direct incorporation into heterocyclic scaffolds. This bench-stable, moisture-tolerant reagent streamlines synthesis of bioactive thiazole derivatives for medicinal chemistry applications.

Application

Ethyl 2-aminothiazole-5-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds prevalent in bioactive molecules. Its amino and ester functionalities offer orthogonal reactivity for derivatization via amidation, alkylation, or transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • In-stock
      Ethyl 3-ethoxy-2-propenoate|CS-W002052
      1001-26-9
    • null|null
      17356-08-0
    • ~72%
    • In-stock
      Ethyl 2-aminothiazole-5-carboxylate|CS-D0703
      32955-21-8

    References

    • EP2615092 A1, ; Paragraph 0095; 0096 ;
  • Route2
    • null|null
      105-39-5
    • null|null
      17356-08-0
    • null|null
      109-94-4
    • ~%
    • In-stock
      Ethyl 2-aminothiazole-5-carboxylate|CS-D0703
      32955-21-8

    References

    • WO2004/80996 A1, ; Page 26; 46-47 ; WO 2004/080996 A1
  • Route3

    References

    • Arkivoc, , vol. 2010, # 6 p. 32 - 38

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   0.902
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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