Lot numbers can be found on the outside label of a product:
(S)-1-(4-Fluorophenyl)ethylamine
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CAS No. 66399-30-2
- Cat. No. CS-D0021
- Purity≥97%
- MDL No.MFCD03092999
*For research and further manufacturing use only, not for direct human use.
Structure of 66399-30-2
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General Information
- CAS No. 66399-30-2
- Cat. No. CS-D0021
- Purity ≥97%
- MDL No. MFCD03092999
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₀FN
- Molecular Weight 139.17
- Synonym(s) 1-bromo-2,3,4-trichloro-1,1,2-trifluorobutane
- SMILES N[C@@H](C)C(C=C1)=CC=C1F
Description
(S)-1-(4-Fluorophenyl)ethylamine is a chiral building block featuring a stereodefined amine adjacent to a fluorinated phenyl ring. This configuration imparts distinct reactivity and recognition properties in asymmetric synthesis, particularly in the construction of bioactive molecules. The fluorine substituent enhances metabolic stability and modulates electronic effects, enabling precise control in medicinal chemistry applications.
Application
(S)-1-(4-Fluorophenyl)ethylamine serves as a chiral building block for pharmaceutical intermediates, enabling stereoselective synthesis of bioactive molecules. Its bench-stable, crystalline form facilitates handling and purification, while the aromatic fluorine enhances metabolic stability. It functions effectively in amide coupling, reductive amination, and asymmetric catalysis, providing access to diverse heterocyclic scaffolds and API precursors under standard reaction conditions.
Synthesis
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Route1
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444643-11-2 -
444643-12-3
- ~%
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In-stock
66399-30-2
References
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US6797842 B2, ; Page column 28-29 ;
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Route2
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444643-11-2
- ~99%
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In-stock
66399-30-2
References
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Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro Chemistry Letters, 2004 , vol. 33, # 11 p. 1424 - 1425
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Route3
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1384454-53-8
- ~%
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In-stock
66399-30-2
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In-stock
374898-01-8
References
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Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS09
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Signal Word : Danger
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UN#: 2735
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314-H411
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Precautionary Statements : P260-P264-P270-P273-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P330-P363-P391-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 26.02
- LogP 1.8454
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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