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CS-W001157 4
Total: USD 88.00

1-(3-Fluorophenyl)ethanamine

  • CAS No. 74788-45-7

  • Cat. No. CS-0040943
  • Purity≥98%
  • MDL No.MFCD04038308

*For research and further manufacturing use only, not for direct human use.

1-(3-Fluorophenyl)ethanamine|CS-0040943

Structure of 74788-45-7

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General Information

  • CAS No. 74788-45-7
  • Cat. No. CS-0040943
  • Purity ≥98%
  • MDL No. MFCD04038308
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀FN
  • Molecular Weight 139.17
  • Synonym(s) 3-Fluoro-alpha-methylbenzenemethanamine
  • SMILES NC(C)C1=CC=CC(F)=C1

Description

1-(3-Fluorophenyl)ethanamine is a bench-stable, moisture-tolerant amine featuring a para-fluorinated phenyl ring that enhances metabolic stability. This electron-deficient aryl moiety integrates readily into bioactive scaffolds, enabling efficient coupling in late-stage functionalization and pharmaceutical synthesis workflows.

Application

1-(3-Fluorophenyl)ethanamine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard amine functionalization. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the pendant ethylamine side chain facilitates conjugation via amide coupling, reductive amination, or alkylation. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multistep syntheses of pharmaceutical intermediates and CNS-targeted compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.8454
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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