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CS-W001157 4
Total: USD 88.00

(5-Methylthiophen-2-yl)methanol

  • CAS No. 63826-59-5

  • Cat. No. CS-0152994
  • Purity≥98%
  • MDL No.MFCD06202627

*For research and further manufacturing use only, not for direct human use.

(5-Methylthiophen-2-yl)methanol|CS-0152994

Structure of 63826-59-5

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General Information

  • CAS No. 63826-59-5
  • Cat. No. CS-0152994
  • Purity ≥98%
  • MDL No. MFCD06202627
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈OS
  • Molecular Weight 128.19
  • Synonym(s) 5-Methyl-2-thiopheneMethanol
  • SMILES CC1=CC=C(CO)S1

Description

This bench-stable, moisture-tolerant building block features a methylthiophene core with a reactive hydroxymethyl group. The para-positioned methylthio moiety enhances electron density, enabling efficient coupling in cross-coupling and functionalization reactions. Its solubility profile supports use under standard conditions for synthetic organic chemistry applications.

Application

(5-Methylthiophen-2-yl)methanol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized thiophene derivatives. Its benzylic alcohol functionality facilitates oxidation to the corresponding aldehyde or carboxylic acid, and it participates reliably in coupling reactions such as Suzuki-Miyaura and Stille transformations. The molecule exhibits good bench stability and is compatible with common protecting group strategies, making it a practical choice for medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1

    References

    • FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis Patent: WO2011/61214 A1, 2011 ; Location in patent: Page/Page column 95 ; WO 2011/061214 A1
  • Route2

    References

    • SMITHKLINE BEECHAM CORPORATION Patent: WO2007/65093 A2, 2007 ; Location in patent: Page/Page column 76 ;
  • Route3

    References

    • Kharchenko, V. G.; Gubina, T. I.; Markushina, I. A. Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, # 2 p. 343 - 347 Zhurnal Organicheskoi Khimii, 1982 , # 2 p. 394 - 399

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.54882
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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