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CS-W001157 4
Total: USD 88.00

5-Methyl-2-thiophenecarboxaldehyde

  • CAS No. 13679-70-4

  • Cat. No. CS-W018539
  • Purity≥98%
  • MDL No.MFCD00005434

*For research and further manufacturing use only, not for direct human use.

5-Methyl-2-thiophenecarboxaldehyde|CS-W018539

Structure of 13679-70-4

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General Information

  • CAS No. 13679-70-4
  • Cat. No. CS-W018539
  • Purity ≥98%
  • MDL No. MFCD00005434
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆OS
  • Molecular Weight 126.18
  • Synonym(s) None
  • SMILES O=CC1=CC=C(C)S1

Description

5-Methyl-2-thiophenecarboxaldehyde features a conjugated thiophene core with an aldehyde and methyl group positioned for orthogonal reactivity. This bench-stable, moisture-tolerant heterocycle integrates readily into cross-coupling and condensation workflows, enabling efficient access to functionalized thienyl scaffolds in synthetic and medicinal chemistry applications.

Application

5-Methyl-2-thiophenecarboxaldehyde serves as a versatile building block in heterocyclic synthesis, enabling efficient access to functionalized thiophene derivatives. Its aldehyde functionality facilitates nucleophilic additions, condensations, and coupling reactions under mild conditions. The methyl group provides steric and electronic modulation, enhancing stability and selectivity in downstream transformations. This compound functions effectively in medicinal chemistry scaffolds and materials science applications, offering reliable reactivity and ease of purification.

Synthesis

  • Route1
    • In-stock
      2-Methylthiophene|CS-W011331
      554-14-3
    • null|null
      68-12-2
    • ~98%
    • In-stock
      5-Methyl-2-thiophenecarboxaldehyde|CS-W018539
      13679-70-4

    References

    • Tanaka, Shota; Tanaka, Daiki; Sugie, Atsushi; Mori, Atsunori Tetrahedron Letters, 2012 , vol. 53, # 9 p. 1173 - 1176
  • Route2
    • In-stock
      2-Methylthiophene|CS-W011331
      554-14-3
    • null|null
      75-44-5
    • null|null
      107-06-2
    • ~%
    • In-stock
      5-Methyl-2-thiophenecarboxaldehyde|CS-W018539
      13679-70-4

    References

    • US5412106 A1, ;
  • Route3
    • In-stock
      2-Methylthiophene|CS-W011331
      554-14-3
    • null|null
      93-61-8
    • ~%
    • In-stock
      5-Methyl-2-thiophenecarboxaldehyde|CS-W018539
      13679-70-4

    References

    • Journal of the Chemical Society, , p. 2130,2134 Journal of Organic Chemistry, , vol. 14, p. 790,795 Journal of the American Chemical Society, , vol. 72, p. 1422 Journal of Organic Chemistry, , vol. 13, p. 635,637

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.86902
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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