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CS-W001157 4
Total: USD 88.00

5-Methylthiophene-2-carboxylic acid

  • CAS No. 1918-79-2

  • Cat. No. CS-W004720
  • Purity≥97%
  • MDL No.MFCD00005439

*For research and further manufacturing use only, not for direct human use.

5-Methylthiophene-2-carboxylic acid|CS-W004720

Structure of 1918-79-2

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General Information

  • CAS No. 1918-79-2
  • Cat. No. CS-W004720
  • Purity ≥97%
  • MDL No. MFCD00005439
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆O₂S
  • Molecular Weight None
  • Synonym(s) 5-methylthiophene-2-carboxylate
  • SMILES O=C(C1=CC=C(C)S1)O

Description

5-Methylthiophene-2-carboxylic acid features a thiophene core functionalized with a methyl group at the 5-position and a carboxylic acid at the 2-position, offering enhanced electron density and stability. This structure enables direct incorporation into conjugated systems, serving as a robust building block for heterocyclic synthesis and materials development under standard conditions.

Application

5-Methylthiophene-2-carboxylic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates. Its fused thiophene core with ortho-carboxylic acid and methyl substituents enables direct derivatization via amide, ester, or decarboxylation reactions. The compound exhibits good bench stability and facilitates efficient functional group manipulation in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      765-58-2
    • null|null
      201230-82-2
    • ~6%
    • In-stock
      5-Methylthiophene-2-carboxylic acid|CS-W004720
      1918-79-2
    • In-stock
      Methyl 5-methylthiophene-2-carboxylate|CS-0133007
      19432-69-0

    References

    • Journal of Organic Chemistry, , vol. 60, # 26 p. 8336 - 8340
  • Route2
    • In-stock
      2-Methylthiophene|CS-W011331
      554-14-3
    • null|null
      124-38-9
    • ~77%
    • In-stock
      5-Methylthiophene-2-carboxylic acid|CS-W004720
      1918-79-2

    References

    • Nemoto, Koji; Onozawa, Satoru; Konno, Megumi; Morohashi, Naoya; Hattori, Tetsutaro Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 3 p. 369 - 371
  • Route3
    • null|null
      765-58-2
    • null|null
      67-56-1
    • null|null
      201230-82-2
    • ~6%
    • In-stock
      5-Methylthiophene-2-carboxylic acid|CS-W004720
      1918-79-2
    • In-stock
      Methyl 5-methylthiophene-2-carboxylate|CS-0133007
      19432-69-0

    References

    • Journal of Organic Chemistry, , vol. 60, # 26 p. 8336 - 8340

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.75472
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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