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CS-W001157 4
Total: USD 88.00

2-Thiophenemethanol

  • CAS No. 636-72-6

  • Cat. No. CS-0022380
  • Purity≥98%
  • MDL No.MFCD00005454

*For research and further manufacturing use only, not for direct human use.

2-Thiophenemethanol|CS-0022380

Structure of 636-72-6

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General Information

  • CAS No. 636-72-6
  • Cat. No. CS-0022380
  • Purity ≥98%
  • MDL No. MFCD00005454
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆OS
  • Molecular Weight 114.17
  • Synonym(s) None
  • SMILES OCC1=CC=CS1

Description

2-Thiophenemethanol features a thiophene ring fused with a reactive benzylic alcohol, enabling straightforward derivatization. This bench-stable compound integrates readily into synthetic sequences requiring heterocyclic scaffolds with pendant functional handles. The hydroxymethyl group facilitates coupling reactions under standard conditions.

Application

2-Thiophenemethanol serves as a versatile building block in synthetic organic chemistry, enabling efficient functionalization at the benzylic position. Its thiophene ring imparts stability and favorable electronic properties, while the primary alcohol facilitates derivatization via oxidation, esterification, or coupling reactions. The compound exhibits good bench stability and is readily purified by distillation or chromatography, making it suitable for use in medicinal chemistry, catalyst design, and the synthesis of heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • Vu, Thi-Thu-Ha; Kumbhar, Pramod S.; Figueras, Francois Advanced Synthesis and Catalysis, 2003 , vol. 345, # 4 p. 493 - 496
  • Route2
    • In-stock
      2-Thiophenecarboxaldehyde|CS-W013657
      98-03-3
    • null|null
      74497-02-2
    • ~4%
    • N-(Thiophen-2-ylmethyl)aniline|CS-1675432
      40625-28-3
    • In-stock
      2-Thiophenemethanol|CS-0022380
      636-72-6

    References

    • Tetrahedron Letters, , vol. 49, # 6 p. 965 - 969
  • Route3
    • In-stock
      2-Thiophenecarboxaldehyde|CS-W013657
      98-03-3
    • null|null
      106-96-7
    • ~14%
    • 1-(Thiophen-2-yl)but-3-yn-1-ol|CS-0436848
      38597-97-6
    • In-stock
      2-Thiophenemethanol|CS-0022380
      636-72-6

    References

    • Tetrahedron Letters, , vol. 39, # 22 p. 3655 - 3658

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.2404
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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