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CS-W001157 4
Total: USD 88.00

2-(4-Aminophenyl)propanoic acid

  • CAS No. 59430-62-5

  • Cat. No. CS-0113072
  • Purity≥96%
  • MDL No.MFCD00800233

*For research and further manufacturing use only, not for direct human use.

2-(4-Aminophenyl)propanoic acid|CS-0113072

Structure of 59430-62-5

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General Information

  • CAS No. 59430-62-5
  • Cat. No. CS-0113072
  • Purity ≥96%
  • MDL No. MFCD00800233
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) 4-aminohydratropic acid
  • SMILES CC(C1=CC=C(N)C=C1)C(O)=O

Description

This bench-stable arylalanine derivative features a para-aminophenyl moiety linked to a propanoic acid side chain, enabling direct incorporation into peptide conjugates and bioconjugation workflows. The electron-rich aromatic ring facilitates efficient coupling reactions under standard conditions, while the primary amine supports further functionalization.

Application

2-(4-Aminophenyl)propanoic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling efficient access to biologically relevant arylalanine scaffolds. Its ortho-substituted aniline functionality facilitates direct coupling reactions and downstream derivatization, while the carboxylic acid group supports amide formation and esterification under standard conditions. The compound exhibits good bench stability and is compatible with common purification methods, making it suitable for both small-scale medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1

    References

    • Gruenenthal GmbH Patent: US2009/156590 A1, 2009 ; Location in patent: Page/Page column 39; 46; 56 ; US 20090156590 A1
  • Route2
    • null|null
      65784-32-9
    • ~99%
    • 2-(4-Aminophenyl)propanoic acid|CS-0113072
      59430-62-5

    References

    • Gruenenthal GmbH Patent: US2009/156590 A1, 2009 ; Location in patent: Page/Page column 63-64 ; US 20090156590 A1
  • Route3
    • null|null
      64-17-5
    • In-stock
      2-(4-Nitrophenyl)propanoic acid|CS-0046204
      19910-33-9
    • null|null
      7440-05-3
    • ~68%
    • 2-(4-Aminophenyl)propanoic acid|CS-0113072
      59430-62-5

    References

    • Ekwuribe, Nnochiri Nkem; Riggs-Sauthier, Jennifer A. Patent: US2002/49186 A1, 2002 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   1.4569
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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