4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine

Name: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 568577-88-8
Cat. No. CS-W014555
Purity≥96%
MDL No.MFCD04112544

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine|CS-W014555

Structure of 568577-88-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 568577-88-8
Cat. No. CS-W014555
Purity ≥96%
MDL No. MFCD04112544
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₄BNO₃
Molecular Weight 289.18
Synonym(s) 4-Morpholinophenylboronic Acid Pinacol Ester
SMILES CC1(C)C(C)(C)OB(C2=CC=C(N3CCOCC3)C=C2)O1

Description

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine features a boronate ester handle flanked by a para-substituted phenyl ring and a morpholine heterocycle. This combination delivers enhanced solubility and stability under standard conditions, enabling efficient coupling in Suzuki-Miyaura reactions. The electron-rich morpholine moiety improves reactivity in cross-coupling processes while maintaining bench-stable handling characteristics.

Application

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine serves as a versatile boronate building block in Suzuki-Miyaura cross-coupling reactions. The morpholine moiety provides solubility and functional group tolerance, while the stable tetramethylboronate group enables efficient coupling with aryl halides under mild conditions. This reagent facilitates rapid access to biaryl architectures common in medicinal chemistry and materials science, offering excellent bench stability and straightforward purification.

Synthesis

Route1
- In-stock
  
  30483-75-1
- 25015-63-8
- ~84%
- In-stock
  
  568577-88-8
References
- SMITHKLINE BEECHAM CORPORATION Patent: WO2004/13138 A2, 2004 ; Location in patent: Page 23; 24 ; WO 2004/013138 A2
Route2
- In-stock
  
  70291-67-7
- In-stock
  
  73183-34-3
- ~85%
- In-stock
  
  568577-88-8
References
- Yamamoto, Tetsuya; Morita, Tomoyuki; Takagi, Jun; Yamakawa, Tetsu Organic Letters, 2011 , vol. 13, # 21 p. 5766 - 5769
Route3
- In-stock
  
  30483-75-1
- In-stock
  
  73183-34-3
- ~59%
- In-stock
  
  568577-88-8
References
- Patel, Gautam; Karver, Caitlin E.; Behera, Ranjan; Guyett, Paul J.; Sullenberger, Catherine; Edwards, Peter; Roncal, Norma E.; Mensa-Wilmot, Kojo; Pollastri, Michael P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3820 - 3832

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 30.93
LogP 1.8224
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Synthesis Organometallic Reagents Organoboron Boronic Acids and Derivatives

Key Words

568577-88-8 sigma568577-88-8 manufacturer568577-88-8 price568577-88-8 structure568577-88-8 SDSbuy 568577-88-8568577-88-8 supplier568577-88-8 uses568577-88-8 molecular weightprice of 568577-88-8568577-88-8 chemical name formula of 568577-88-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine

CAS No. 568577-88-8

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words