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CS-W001157 4
Total: USD 88.00

4-(4-Chlorophenyl)morpholine

  • CAS No. 70291-67-7

  • Cat. No. CS-0157478
  • Purity≥98%
  • MDL No.MFCD09038510

*For research and further manufacturing use only, not for direct human use.

4-(4-Chlorophenyl)morpholine|CS-0157478

Structure of 70291-67-7

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General Information

  • CAS No. 70291-67-7
  • Cat. No. CS-0157478
  • Purity ≥98%
  • MDL No. MFCD09038510
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂ClNO
  • Molecular Weight 197.66
  • Synonym(s) N-p-Chlorphenyl-morpholin
  • SMILES C1=C(C=CC(=C1)N2CCOCC2)Cl

Description

4-(4-Chlorophenyl)morpholine is a bench-stable, electron-rich heterocycle featuring a chlorinated phenyl ring linked via a morpholine moiety. This structural combination enables effective integration into bioactive scaffolds and synthetic intermediates requiring enhanced solubility and metabolic stability in pharmaceutical development workflows.

Application

4-(4-Chlorophenyl)morpholine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its stable aryl-morpholine motif exhibits favorable solubility and functional group tolerance, facilitating straightforward derivatization via palladium-catalyzed cross-coupling or electrophilic substitution. The compound functions effectively in both small-molecule synthesis and process development workflows.

Synthesis

  • Route1
    • null|null
      110-91-8
    • In-stock
      1-Bromo-4-chlorobenzene|CS-0015927
      106-39-8
    • ~96%
    • In-stock
      4-(4-Chlorophenyl)morpholine|CS-0157478
      70291-67-7

    References

    • Kim, Min; Chang, Sukbok Organic Letters, 2010 , vol. 12, # 7 p. 1640 - 1643
  • Route2
    • null|null
      110-91-8
    • In-stock
      1-Chloro-4-iodobenzene|CS-W007395
      637-87-6
    • ~90%
    • In-stock
      4-(4-Chlorophenyl)morpholine|CS-0157478
      70291-67-7

    References

    • Wang, Zhe; Fu, Hua; Jiang, Yuyang; Zhao, Yufen Synlett, 2008 , # 16 p. 2540 - 2546
  • Route3
    • null|null
      110-91-8
    • null|null
      41605-52-1
    • ~76%
    • In-stock
      4-(4-Chlorophenyl)morpholine|CS-0157478
      70291-67-7

    References

    • Anderson, Kevin W.; Mendez-Perez, Maria; Priego, Julian; Buchwald, Stephen L. Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9563 - 9573

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   2.1766
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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