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CS-W001157 4
Total: USD 88.00

1-Chloro-4-iodobenzene

  • CAS No. 637-87-6

  • Cat. No. CS-W007395
  • Purity≥98%
  • MDL No.MFCD00001053

*For research and further manufacturing use only, not for direct human use.

1-Chloro-4-iodobenzene|CS-W007395

Structure of 637-87-6

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General Information

  • CAS No. 637-87-6
  • Cat. No. CS-W007395
  • Purity ≥98%
  • MDL No. MFCD00001053
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClI
  • Molecular Weight 238.45
  • Synonym(s) P-CHLOROIODOBENZENE; 1-Chloro-4-iodobenzene
  • SMILES IC1=CC=C(Cl)C=C1

Description

1-Chloro-4-iodobenzene is a bifunctional aryl halide featuring complementary reactivity between chlorine and iodine. This ortho-directed coupling partner enables seamless cross-coupling transformations in palladium-catalyzed processes, where the iodine group facilitates rapid activation while the chloride remains inert. The molecule's stability under standard conditions supports reliable use in synthetic sequences requiring selective functionalization.

Synthesis

  • Route1
    • null|null
      106-47-8
    • ~86%
    • In-stock
      1-Chloro-4-iodobenzene|CS-W007395
      637-87-6

    References

    • Kolvari, Eskandar; Amoozadeh, Ali; Koukabi, Nadiya; Otokesh, Somayeh; Isari, Mohsen Tetrahedron Letters, 2014 , vol. 55, # 27 p. 3648 - 3651
  • Route2

    References

    • Thiebes, Christoph; Prakash, G. K. Surya; Petasis, Nicos A.; Olah, George A. Synlett, 1998 , # 2 p. 141 - 142
  • Route3
    • null|null
      108-90-7
    • ~95%
    • In-stock
      1-Chloro-4-iodobenzene|CS-W007395
      637-87-6

    References

    • Rozen, Shlomo; Zamir, Dov Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3552 - 3555

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.9446
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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