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CS-W001157 4
Total: USD 88.00

1-Chloro-2-iodobenzene

  • CAS No. 615-41-8

  • Cat. No. CS-W007543
  • Purity≥98%
  • MDL No.MFCD00001033

*For research and further manufacturing use only, not for direct human use.

1-Chloro-2-iodobenzene|CS-W007543

Structure of 615-41-8

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General Information

  • CAS No. 615-41-8
  • Cat. No. CS-W007543
  • Purity ≥98%
  • MDL No. MFCD00001033
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClI
  • Molecular Weight 238.45
  • Synonym(s) O-IODOCHLOROBENZENE; 1-Chloro-2-iodobenzene
  • SMILES ClC1=C(I)C=CC=C1

Description

1-Chloro-2-iodobenzene is a halogenated aromatic compound featuring ortho-chloro and iodine substituents on the benzene ring. This configuration enables efficient cross-coupling reactions in palladium-catalyzed transformations, offering high reactivity and predictable regiochemistry. The molecule exhibits enhanced stability under standard bench conditions and integrates readily into complex synthetic sequences for pharmaceutical and agrochemical intermediates.

Application

1-Chloro-2-iodobenzene serves as a versatile biaryl coupling precursor in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki, Stille, and Negishi conditions. The ortho-halogen substitution pattern provides predictable reactivity and facilitates selective functionalization. Bench-stable and readily purified by distillation, it functions reliably in multi-step synthesis of pharmaceutical intermediates and advanced heterocyclic scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.9446
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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