1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine

Name: 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine
Brand: ChemScene
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CAS No. 852227-96-4
Cat. No. CS-0061105
Purity≥98%
MDL No.None

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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine|CS-0061105

Structure of 852227-96-4

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General Information

CAS No. 852227-96-4
Cat. No. CS-0061105
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₇H₂₆BNO₂
Molecular Weight 287.20
Synonym(s) 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine
SMILES CC1(C)C(C)(C)OB(C2=CC=C(C=C2)N3CCCCC3)O1

Description

1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine is a stable boronate ester enabling efficient Suzuki-Miyaura coupling. The piperidine moiety provides favorable solubility and handles well under standard conditions. This building block integrates readily into complex molecular architectures.

Application

1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. Its stable boronate ester group enables efficient C–C bond formation under mild conditions, with excellent functional group tolerance and bench stability. The piperidine moiety provides a readily modifiable nitrogen-containing scaffold useful in medicinal chemistry and process development.

Synthesis

Route1
- In-stock
  
  22148-20-5
- In-stock
  
  73183-34-3
- ~88%
- In-stock
  
  852227-96-4
References
- Organic and Biomolecular Chemistry, , vol. 12, # 10 p. 1603 - 1610

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P302+P352-P330-P362-P501

Quality Control

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Computational Chemistry Data

TPSA 21.7
LogP 2.9761
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine

CAS No. 852227-96-4

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