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CS-W001157 4
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2-Fluoro-5-hydroxypyridine

  • CAS No. 55758-32-2

  • Cat. No. CS-W019887
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-hydroxypyridine|CS-W019887

Structure of 55758-32-2

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General Information

  • CAS No. 55758-32-2
  • Cat. No. CS-W019887
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄FNO
  • Molecular Weight 113.09
  • Synonym(s) 6-Fluoro-3-pyridinol; 2-Fluoro-5-hydroxypyridine
  • SMILES OC1=CC=C(F)N=C1

Description

2-Fluoro-5-hydroxypyridine features a strategically positioned hydroxyl group flanked by fluorine and nitrogen, enabling unique reactivity in cross-coupling and functionalization workflows. This electron-deficient heterocycle delivers enhanced stability under standard conditions while supporting efficient derivatization in medicinal chemistry applications.

Application

2-Fluoro-5-hydroxypyridine serves as a versatile building block for functionalized pyridine scaffolds, enabling direct electrophilic substitution and transition-metal-catalyzed coupling reactions. The ortho-fluoro and para-hydroxyl groups provide complementary reactivity for sequential derivatization, while the compound exhibits sufficient bench stability for routine handling. Its defined regiochemistry facilitates precise construction of heterocyclic motifs in medicinal chemistry and agrochemical synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.9263
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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