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CS-W001157 4
Total: USD 88.00

6-Fluoro-4-iodopyridin-3-ol

  • CAS No. 1034467-29-2

  • Cat. No. CS-0179214
  • Purity≥96%
  • MDL No.MFCD16611043

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-4-iodopyridin-3-ol|CS-0179214

Structure of 1034467-29-2

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General Information

  • CAS No. 1034467-29-2
  • Cat. No. CS-0179214
  • Purity ≥96%
  • MDL No. MFCD16611043
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FINO
  • Molecular Weight 238.99
  • Synonym(s) 6-Fluoro-4-iodo-3-pyridinol
  • SMILES OC1=C(I)C=C(F)N=C1

Description

6-Fluoro-4-iodopyridin-3-ol features a trifunctional pyridine core bearing fluorine, iodine, and hydroxyl groups at strategic positions. This electron-deficient heterocycle enables direct cross-coupling transformations under palladium catalysis. The phenolic OH group supports in situ activation for derivatization, while the ortho-iodine facilitates selective C–C bond formation. Bench-stable and moisture-tolerant, it serves as a key building block in kinase inhibitor and agrochemical synthesis.

Application

6-Fluoro-4-iodopyridin-3-ol serves as a versatile building block for late-stage functionalization in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive iodide and electron-deficient pyridine core. The fluorinated position enhances metabolic stability, while the phenolic hydroxyl group allows for derivatization or protection. Bench-stable and compatible with standard coupling conditions, it facilitates efficient access to complex heterocyclic scaffolds found in pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5309
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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