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Structure of 1034467-29-2
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6-Fluoro-4-iodopyridin-3-ol features a trifunctional pyridine core bearing fluorine, iodine, and hydroxyl groups at strategic positions. This electron-deficient heterocycle enables direct cross-coupling transformations under palladium catalysis. The phenolic OH group supports in situ activation for derivatization, while the ortho-iodine facilitates selective C–C bond formation. Bench-stable and moisture-tolerant, it serves as a key building block in kinase inhibitor and agrochemical synthesis.
6-Fluoro-4-iodopyridin-3-ol serves as a versatile building block for late-stage functionalization in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive iodide and electron-deficient pyridine core. The fluorinated position enhances metabolic stability, while the phenolic hydroxyl group allows for derivatization or protection. Bench-stable and compatible with standard coupling conditions, it facilitates efficient access to complex heterocyclic scaffolds found in pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: