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CS-W001157 4
Total: USD 88.00

2-Fluoro-5-methylpyridine

  • CAS No. 2369-19-9

  • Cat. No. CS-W019967
  • Purity≥97%
  • MDL No.MFCD00041225

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-methylpyridine|CS-W019967

Structure of 2369-19-9

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General Information

  • CAS No. 2369-19-9
  • Cat. No. CS-W019967
  • Purity ≥97%
  • MDL No. MFCD00041225
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FN
  • Molecular Weight 111.12
  • Synonym(s) 5-Methyl-2-fluoropyridine; Fluoromethylpyridine3
  • SMILES CC1=CN=C(F)C=C1

Description

2-Fluoro-5-methylpyridine serves as a key heterocyclic building block in medicinal chemistry, featuring a fluorine atom at the 2-position and a methyl group at the 5-position on the pyridine ring. This electronic and steric profile enhances metabolic stability and modulates bioavailability, making it valuable for drug discovery applications.

Application

2-Fluoro-5-methylpyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling reactions. Its fluorine and methyl substituents provide orthogonal reactivity and enhanced metabolic stability, while its bench-stable nature facilitates handling and purification in multi-step syntheses.

Synthesis

  • Route1

    References

    • Liu, Yuxiu; Zhao, Qiqi; Wang, Qingmin; Li, Heng; Huang, Runqiu; Li, Yonghong Journal of Fluorine Chemistry, 2005 , vol. 126, # 3 p. 345 - 348
  • Route2
    • null|null
      108-99-6
    • ~15%
    • In-stock
      2-Fluoro-5-methylpyridine|CS-W019967
      2369-19-9
    • In-stock
      2-Fluoro-3-methylpyridine|CS-W016622
      2369-18-8

    References

    • Tetrahedron Letters, , vol. 28, # 3 p. 255 - 258
  • Route3

    References

    • Synthetic Communications, , vol. 24, # 16 p. 2387 - 2392

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.52912
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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