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CS-W001157 4
Total: USD 88.00

2-Fluoro-3-methylpyridine

  • CAS No. 2369-18-8

  • Cat. No. CS-W016622
  • Purity≥98%
  • MDL No.MFCD00041223

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-methylpyridine|CS-W016622

Structure of 2369-18-8

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General Information

  • CAS No. 2369-18-8
  • Cat. No. CS-W016622
  • Purity ≥98%
  • MDL No. MFCD00041223
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FN
  • Molecular Weight None
  • Synonym(s) 2-Fluoro-3-picoline
  • SMILES C1=C(C(=NC=C1)F)C

Description

2-Fluoro-3-methylpyridine is a fluorinated heterocycle featuring a methyl group at the 3-position and a fluorine atom at the 2-position, offering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into pharmaceutical intermediates and agrochemicals, serving as a key building block for bioactive molecules.

Application

2-Fluoro-3-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal reactivity profile. The fluorine and methyl groups provide distinct electronic and steric modulation, enhancing regioselectivity in C–H functionalization. Its bench-stable nature and compatibility with common protecting group strategies facilitate integration into multi-step syntheses of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • Journal of Fluorine Chemistry, , vol. 132, # 8 p. 541 - 547
  • Route2
    • null|null
      108-99-6
    • ~27%
    • In-stock
      2-Fluoro-5-methylpyridine|CS-W019967
      2369-19-9
    • In-stock
      2-Fluoro-3-methylpyridine|CS-W016622
      2369-18-8

    References

    • Tetrahedron Letters, , vol. 28, # 3 p. 255 - 258
  • Route3

    References

    • Synthetic Communications, , vol. 24, # 16 p. 2387 - 2392

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.52912
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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