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CS-W001157 4
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2-Fluoro-5-methoxypyridine

  • CAS No. 136888-79-4

  • Cat. No. CS-W021695
  • Molecule weight127.12
  • Purity≥95%
  • MDL No.MFCD13185604

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-methoxypyridine|CS-W021695

Structure of 136888-79-4

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General Information

  • CAS No. 136888-79-4
  • Cat. No. CS-W021695
  • Purity ≥95%
  • MDL No. MFCD13185604
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) Pyridine, 2-fluoro-5-methoxy- (9CI)
  • SMILES COC1=CN=C(F)C=C1

Description

2-Fluoro-5-methoxypyridine is a bench-stable heterocyclic building block featuring a fluorine atom at the 2-position and a methoxy group at the 5-position. This electron-deficient pyridine scaffold enables direct coupling reactions, facilitating access to bioactive compounds in medicinal chemistry and agrochemical development.

Application

2-Fluoro-5-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling reactions. Its fluorine and methoxy groups offer orthogonal reactivity and enhanced metabolic stability, while the compound exhibits excellent bench stability and ease of purification—ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.2293
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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