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CS-W001157 4
Total: USD 88.00

2,5-Difluoropyridine

  • CAS No. 84476-99-3

  • Cat. No. CS-W003160
  • Purity≥97%
  • MDL No.MFCD04114191

*For research and further manufacturing use only, not for direct human use.

2,5-Difluoropyridine|CS-W003160

Structure of 84476-99-3

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General Information

  • CAS No. 84476-99-3
  • Cat. No. CS-W003160
  • Purity ≥97%
  • MDL No. MFCD04114191
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃F₂N
  • Molecular Weight 115.08
  • Synonym(s) Pyridine, 2,5-difluoro-; 2,5-Difluoropyridine
  • SMILES FC1=CN=C(F)C=C1

Description

2,5-Difluoropyridine serves as a key heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and modulated electron density. The strategically positioned fluorine atoms enable directed functionalization via cross-coupling reactions, while the electron-deficient core facilitates nucleophilic substitution. This bench-stable, moisture-tolerant reagent integrates efficiently into complex molecular architectures.

Application

2,5-Difluoropyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling site-selective functionalization via cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity profile, enhanced by the electron-withdrawing effect of fluorine atoms, facilitates efficient C–H activation and late-stage diversification. Bench-stable and compatible with standard reaction conditions, it functions as a key scaffold for heterocyclic API development and catalyst design.

Synthesis

  • Route1

    References

    • Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910
  • Route2

    References

    • Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910
  • Route3
    • 3-Chloro-2,5-difluoro-6-hydrazinylpyridine|CS-0136733
      851179-04-9
    • ~72%
    • In-stock
      2,5-Difluoropyridine|CS-W003160
      84476-99-3

    References

    • Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P302+P352

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.3598
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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